Amaury FARCE, PhD
Associate Professor
Contact Information
Projects
PPM6
Principal InvestigatorStudy of a phosphatase essential for the Plasmodium replication cycle, PPM6, in collaboration with Pr ALIOUAT El Moukhtar from Institut Pasteur, Lille
View Project →GPR35
Team MemberElucidation of the atomic-level pharmacology of GPR35 and identification of new, highly selective agonists, ideally possessing a biased signaling profile toward different biological response cascades.
View Project →Toxoplasmosis
Principal InvestigatorStudy of toxic compounds for the cystic form of Toxoplasma gondii, and identification of the molecular target, in collaboration with Dr GISSOT Mathieu from Institut Pasteur, Lille
View Project →FFAR4 (GPR120)
Principal InvestigatorLeveraged homology modeling and molecular dynamics to map the structural activation of FFAR4 (GPR120), identifying novel pharmacophore constraints for the next generation of anti-obesity therapeutics.
View Project →Nuclear receptors
Principal InvestigatorStudy of nuclear receptors involved in inflammatory diseases, including PPAR, glucocorticoid receptor, steroid receptors, etc.
View Project →P2X7
Team MemberElucidation of the mechanism of action of the homotrimeric channel receptor P2X7 and identification of novel positive and negative allosteric modulators
View Project →PPM9
Principal InvestigatorStudy of a phosphatase essential for the Plasmodium replication cycle, PPM9, in collaboration with Pr ALIOUAT El Moukhtar from Institut Pasteur, Lille
View Project →P28GST - Design and evaluation of pharmacological tools for studying the immunomodulatory function of a parasitic protein in CD
Principal InvestigatorDeciphered the dual anti-inflammatory mechanisms of the parasitic protein shP28GST through in silico modeling and in vivo validation to optimize future treatments for Crohn’s Disease
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